KYEAL’S PERSONALIZED PRECISION WELLNESS PROGRAMS ARE ROOTED IN EVIDENCE-BASED SCIENCE, GLOBAL STANDARDS, AND VALIDATED RESEARCH METHODOLOGIES. OUR APPROACH INTEGRATES:

INTERNATIONAL GUIDELINES & SCIENTIFIC EVIDENCE

DNA ANALYSIS USING BUCCAL SWABS, LEVERAGING VALIDATED GENE PANELS FOR NUTRIGENOMICS, METABOLISM, AND PHARMACOGENOMICS.

MARKER INTERPRETATION IS BASED ON REFERENCES SUCH AS FDA, CPIC, EMA, SWISSMEDIC, PMDA, HCSC FOR DRUG-GENOME INTERACTIONS.

CLINICAL RECOMMENDATIONS AND DISEASE RISK PROFILING FOLLOW CURRENT BEST PRACTICES AS PUBLISHED IN PEER-REVIEWED JOURNALS INCLUDING NATURE, AMERICAN JOURNAL OF CLINICAL NUTRITION (AJCN), THE LANCET, AND JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS.

METHODOLOGY

SAMPLE QUALITY AND DNA SEQUENCING FOLLOW ISO-CERTIFIED PROTOCOLS.

VARIANT INTERPRETATION USES ESTABLISHED DATABASES LIKE GWAS CATALOG, PHARMGKB, CLINVAR, AND OMIM.

NUTRITION, LIFESTYLE, AND SUPPLEMENT ADVICE GROUNDED IN THE RESULTS OF EXTENSIVE GENETIC-ASSOCIATION STUDIES (E.G., MTHFR AND FOLATE/B9/HEART HEALTH, SOD2 FOR ANTIOXIDANT STATUS, LCT/MCM6 FOR LACTOSE TOLERANCE, PPARG FOR FAT METABOLISM).

DISEASE RISK SCORES ARE REFERENCED AGAINST ROBUST POPULATION STUDIES.

SCIENTIFIC DATA & SERVICE VALIDATION

GENOTYPE-DIET RECOMMENDATIONS ARE BACKED BY META-ANALYSES, SUCH AS QI ET AL. (AJCN: “GENE–DIET INTERACTION AND VITAMIN STATUS”) AND ZEISEL (NATURE REVIEWS GENETICS: “NUTRITIONAL GENOMICS: THE IMPACT OF DIETARY INTERVENTION”).

OUR ALGORITHM AND REPORTS CITE CLINICAL TRIALS, E.G., KHERA ET AL., NEJM (“GENETIC RISK, ADHERENCE TO A HEALTHY LIFESTYLE, AND CORONARY DISEASE”).

SUPPLEMENT PERSONALIZATION REFERENCES RESEARCH ON FUNCTIONAL NUTRIENT METABOLISM (E.G., METHYLATED VITAMINS FOR MTHFR VARIANT CARRIERS, AS PER GOTTESMAN ET AL., PHARMACOGENOMICS JOURNAL).

FOOD ALLERGY AND INTOLERANCE RECOMMENDATIONS ARE BASED ON STUDIES LIKE “GENETICS OF FOOD ALLERGY AND INTOLERANCE” (ALLERGY, 2021).

CLIENT & INSTITUTIONAL AFFILIATIONS

ASSOCIATED WITH KANNUR UNIVERSITY INCUBATION & INNOVATION CENTRE, ABIZEN NUTRITION PRIVATE LIMITED.

REPORTS AND SOLUTIONS DEVELOPED IN COLLABORATION WITH CLINICAL GENETICISTS, REGISTERED DIETITIANS, AND PHARMACOGENOMIC EXPERTS.

LANDMARK REFERENCES AND REVIEWS

1.INTERNATIONAL HUMAN GENOME SEQUENCING CONSORTIUM. FINISHING THE EUCHROMATIC SEQUENCE OF THE HUMAN GENOME. NATURE (2004):
HTTPS://WWW.NATURE.COM/ARTICLES/431931A

2.QI Q, ET AL. GENE–DIET INTERACTION AND VITAMIN STATUS. AM J CLIN NUTR.

3.ZEISEL SH. NUTRITIONAL GENOMICS: THE IMPACT OF DIETARY INTERVENTION. NAT REV GENET.

4.GERMAN JB, ET AL. GENETIC DIETETIC: NUTRIGENOMICS AD THE FUTURE OF DIETETIC PRACTICE. J AM DIET ASSOC.

5.CHADWICK R, ET AL. PROCEEDINGS OF THE NUTRITION SOCIETY.

6.MURGIA C, ADAMSKI MM. TRANSLATION OF NUTRITIONAL GENOMICS INTO NUTRITION PRACTICE. NUTRIENTS.
HTTPS://DOI.ORG/10.3390/NU9040366

7.GARG R, SHARMA N, JAIN SK. NUTRIGENOMICS AND NUTRIGENETICS: CONCEPTS AND APPLICATIONS IN NUTRITION RESEARCH AND PRACTICE. ACTA MEDICA INTERNATIONAL.

8.KEATHLEY J, ET AL. A SYSTEMATIC REVIEW AND RECOMMENDATIONS AROUND NUTRIGENETIC EVIDENCE. FRONT NUTR.
HTTPS://WWW.FRONTIERSIN.ORG/JOURNALS/NUTRITION/ARTICLES/10.3389/FNUT.2021.7892
15/PDF

META-ANALYSES AND CLINICAL TRIALS

1.KHERA AV, ET AL. GENETIC RISK, ADHERENCE TO A HEALTHY LIFESTYLE, AND CORONARY DISEASE. NEJM.

2.A RANDOMIZED CONTROLLED TRIAL OF DNA-BASED DIETARY ADVICE FOR CHANGING DIETARY BEHAVIOR:
HTTPS://WWW.NATURE.COM/ARTICLES/S41598-024-55105-6

3.CLINICAL TRIAL REGISTRY: MTHFR MUTATION AND B12/FOLIC ACID—
HTTPS://CLINICALTRIALS.GOV/STUDY/NCT04952324

KEY GUIDELINES AND DATABASES

1.FDA TABLE OF PHARMACOGENOMIC BIOMARKERS:
HTTPS://WWW.FDA.GOV/DRUGS/SCIENCE-AND-RESEARCH-DRUGS/TABLE-
PHARMACOGENOMIC-BIOMARKERS-DRUG-LABELING

2.CPIC CLINICAL PHARMACOGENETICS IMPLEMENTATION CONSORTIUM:
HTTPS://CPICPGX.ORG/GUIDELINES/

3.GWAS CATALOG – HTTPS://WWW.EBI.AC.UK/GWAS/

4.PHARMGKB—CLINICAL PHARMACOGENETICS KNOWLEDGE BASE:
HTTPS://WWW.PHARMGKB.ORG/

5.CLINVAR—NCBI:
HTTPS://WWW.NCBI.NLM.NIH.GOV/CLINVAR/

6.OMIM—ONLINE MENDELIAN INHERITANCE IN MAN:
HTTPS://OMIM.ORG/

7.NATURE – NUTRIGENOMICS COLLECTION:
HTTPS://WWW.NATURE.COM/SUBJECTS/NUTRIGENOMICS

PHARMACOGENOMICS AND NUTRIGENOMICS REVIEWS

1.PHARMACOGENETICS GUIDELINES:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7868558/

2.BANK PC, ET AL. COMPARISON OF GUIDELINES PUBLISHED BY DPWG AND CPIC.

3.RELLING MV, ET AL. CLINICAL IMPLEMENTATION OF PHARMACOGENETICS: LANCET.

4.THE PHARMACOGENOMICS JOURNAL:
HTTPS://WWW.NATURE.COM/TPJ/

5.ABDULLAH-KOOLMEES H, ET AL. PHARMACOGENETICS GUIDELINES: OVERVIEW AND COMPARISON.
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7868558/

6.FERGUSON JF, ET AL. NUTRIGENOMICS, THE MICROBIOME, AND GENE-ENVIRONMENT:
HTTPS://WWW.AHAJOURNALS.ORG/DOI/10.1161/HCG.0000000000000030

APPLICATION & PRACTICE REVIEWS

1.NUTRIGENETICS AND NUTRIGENOMICS: VIEWPOINTS ON THE APPLICATION AND FUTURE PROSPECTS:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC3121546/

2.ADVANCES IN NUTRIGENOMICS AND APPLICATIONS IN PUBLIC HEALTH:
HTTPS://WWW.FOODANDNUTRITIONJOURNAL.ORG/VOLUME10NUMBER3/ADVANCES-IN-
NUTRIGENOMICS-AND-APPLICATIONS-IN-PUBLIC-HEALTH-A-RECENT-UPDATE/

3.BRENNAN L. NUTRIGENOMICS: LESSONS LEARNED AND FUTURE PERSPECTIVES. AM J CLIN NUTR.
HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S0002916522006141

4.KASSEM NM, ET AL. NUTRIGENOMICS AND MICROBIOME SHAPING THE FUTURE OF NUTRITION.
SAUDI J BIOL SCI.
HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S1687157X23009885

SPECIALTY CLINICAL STUDIES

1.MTHFR GENE AND FOLATE METABOLISM:
HTTPS://MEDLINEPLUS.GOV/GENETICS/GENE/MTHFR/

2.MTHFR POLYMORPHISMS AND VITAMIN B12 DEFICIENCY:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC11512882/

3.GENETIC VARIANTS AND FOLIC ACID CLINICAL RELEVANCE:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC10789830/

4.KHAN S, ET AL. MTHFR DEFICIENCY AND PSYCHIATRIC DISEASES:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC11088868/

5.STATPEARLS—PHARMACOGENOMICS OVERVIEW:
HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK617055/

LACTOSE INTOLERANCE & GENE FOODS

1.SWALLOW DM. GENETICS OF LACTASE PERSISTENCE AND LACTOSE INTOLERANCE. ANNU REV GENET.
HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK532285/

2.GENETICS OF LACTOSE INTOLERANCE: AN UPDATED REVIEW:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7551416/

3.MOLECULAR GENETICS OF HUMAN LACTASE DEFICIENCIES:
HTTPS://WWW.TANDFONLINE.COM/DOI/FULL/10.1080/07853890903121033

GWAS AND FOOD GENOMICS

1.LARGE-SCALE GWAS OF FOOD LIKING REVEALS GENETIC BASIS:
HTTPS://WWW.NATURE.COM/ARTICLES/S41467-022-30187-W

2.DISCOVERY OF METHYLENETETRAHYDROFOLATE REDUCTASE ...
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC11088868/

3.APPRAISAL OF GENE-ENVIRONMENT INTERACTIONS IN GWAS:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC9750926/

NUTRITION, DIET, AND PRACTICAL GENOMICS

1.THE DNA-BASED DIET:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC5224962/

2.GENETIC TEST FOR THE PRESCRIPTION OF DIETS:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC8023120/

3.STATPEARLS—LACTOSE INTOLERANCE:
HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK532285/

4.JOURNAL OF NUTRITION, METABOLISM AND HEALTH SCIENCE.
HTTPS://JNMHS.COM/ARCHIVE/VOLUME/6/ISSUE/4/ARTICLE/1918

5.MTHFR CORRELATION WITH FOLIC ACID AND FETAL MALFORMATIONS:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC10627646/

6.FRONTIERS IN NUTRITION—NUTRIGENOMICS:
HTTPS://WWW.FRONTIERSIN.ORG/JOURNALS/NUTRITION/SECTIONS/NUTRIGENOMICS/RESEARCH-
TOPICS

EMERGING RESEARCH AND REVIEWS

1.NATURE REVIEWS GENETICS—SPECIAL COLLECTIONS:
HTTPS://WWW.NATURE.COM/COLLECTIONS/KGKWWQWTVS/

2.PERSONALIZED MEDICINE—EMERGING APPROACHES:
HTTPS://WWW.SCIENCEDIRECT.COM/TOPICS/AGRICULTURAL-AND-BIOLOGICAL-
SCIENCES/NUTRIGENOMICS

3.SCIENCEDIRECT—NUTRIGENOMICS AND PERSONALIZED DIET:
HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S2772502225002884

4.SYSTEMATIC REVIEW OF NUTRIGENOMICS AND CANCER:
HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC8728558/

5.NUTRIGENETICS AND NUTRIGENOMICS: CONCEPTS AND APPS. ACTA MEDICA INT.

DEMONSTRATION OF SCIENTIFIC RIGOR AND EVIDENCE BACKING OUR SERVICE OFFERENINGS.

1.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7923694/

2.HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S0002916522006141

3.HTTPS://JNMHS.COM/ARCHIVE/VOLUME/6/ISSUE/4/ARTICLE/1918

4.HTTPS://WWW.FOODANDNUTRITIONJOURNAL.ORG/VOLUME10NUMBER3/ADVANCES-IN-
NUTRIGENOMICS-AND-APPLICATIONS-IN-PUBLIC-HEALTH-A-RECENT-UPDATE/

5.HTTPS://WWW.SCIENCEDIRECT.COM/SCIENCE/ARTICLE/PII/S1687157X23009885

6.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7868558/

7.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC8728558/

8.HTTPS://WWW.TANDFONLINE.COM/DOI/FULL/10.1080/07853890903121033

9.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC11512882/

10.HTTPS://WWW.AHAJOURNALS.ORG/DOI/10.1161/HCG.0000000000000030

11.HTTPS://WWW.NATURE.COM/TPJ/

12.HTTPS://WWW.FRONTIERSIN.ORG/JOURNALS/NUTRITION/ARTICLES/10.3389/FNUT.2021.789215/PDF

13.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC7551416/

14.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC11088868/

15.HTTPS://WWW.FRONTIERSIN.ORG/JOURNALS/NUTRITION/SECTIONS/NUTRIGENOMICS/RESEARCH-
TOPICS

16.HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK617055/

17.HTTPS://PMC.NCBI.NLM.NIH.GOV/ARTICLES/PMC3121546/

18.HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK532285/

19.HTTPS://CLINICALTRIALS.GOV/STUDY/NCT04952324

20.HTTPS://WWW.NATURE.COM/ARTICLES/S41431-025-01950-6