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REFERENCES

REFERENCES & RESEARCH METHODOLOGY

 

KYEAL’S PERSONALIZED PRECISION WELLNESS PROGRAMS

Kyeal’s programs are founded on evidence-based science, global standards, and validated research methodologies, ensuring a scientifically rigorous and personalized approach to health and wellness.

OUR INTEGRATED APPROACH INCLUDES:

  • International Guidelines & Scientific Evidence:
    All recommendations are aligned with current global clinical standards and best practices.

  • DNA Analysis Using Buccal Swabs:
    Genetic testing is conducted using validated gene panels focused on nutrigenomics, metabolism, and pharmacogenomics.

  • Drug–Genome Interaction Interpretation:
    Variant interpretation references leading regulatory bodies including FDA, CPIC, EMA, Swissmedic, PMDA, and Health Canada (HCSC).

  • Evidence-Based Clinical Recommendations:
    Risk assessments and health recommendations are drawn from peer-reviewed journals such as:

    • Nature

    • The Lancet

    • American Journal of Clinical Nutrition (AJCN)

    • Journal of Nutrigenetics and Nutrigenomics

METHODOLOGY

  • Sample Quality & Sequencing Standards:
    All DNA processing follows ISO-certified protocols to ensure data integrity and accuracy.

  • Robust Variant Interpretation:
    Analysis uses trusted genomic databases including:

    • GWAS Catalog

    • PharmGKB

    • ClinVar

    • OMIM

  • Personalized Nutrition & Lifestyle Guidance:
    Recommendations are grounded in large-scale genetic-association studies, including but not limited to:

    • MTHFR and folate metabolism

    • SOD2 for antioxidant defense

    • LCT/MCM6 for lactose tolerance

    • PPARG for fat metabolism

  • Disease Risk Scoring:
    Assessed using validated population-based studies and risk algorithms.

SCIENTIFIC VALIDATION & DATA SOURCES

  • Gene–Diet Interaction Evidence:
    Genotype-based nutrition advice is supported by meta-analyses and landmark publications such as:

    • Qi et al., AJCN (“Gene–Diet Interaction and Vitamin Status”)

    • Zeisel, Nature Reviews Genetics (“Nutritional Genomics: The Impact of Dietary Intervention”)

  • Clinical Trial References:
    Algorithms and report frameworks are supported by high-impact clinical trials, e.g.:

    • Khera et al., NEJM (“Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease”)

  • Targeted Supplementation Insights:
    Personalization is based on functional nutrient metabolism, including use of methylated vitamins for MTHFR variant carriers (as per Gottesman et al., Pharmacogenomics Journal).

  • Food Allergy & Intolerance Insights:
    Recommendations reference research such as:

    • “Genetics of Food Allergy and Intolerance” (Allergy, 2021)

CLIENT & INSTITUTIONAL AFFILIATIONS

  • Affiliated with Kannur University Incubation & Innovation Centre

  • In partnership with Abizen Nutrition Private Limited

  • Developed in collaboration with:

    • Clinical Geneticists

    • Registered Dietitians

    • Pharmacogenomics Experts

🔬 Landmark References and Reviews

📚 FOUNDATIONAL PUBLICATIONS & REVIEWS

  1. International Human Genome Sequencing Consortium
    Finishing the Euchromatic Sequence of the Human Genome
    Nature (2004)
    https://www.nature.com/articles/431931a

  2. Qi Q, et al.
    Gene–Diet Interaction and Vitamin Status
    American Journal of Clinical Nutrition

  3. Zeisel SH
    Nutritional Genomics: The Impact of Dietary Intervention
    Nature Reviews Genetics

  4. German JB, et al.
    Genetic Dietetic: Nutrigenomics and the Future of Dietetic Practice
    Journal of the American Dietetic Association

  5. Chadwick R, et al.
    Proceedings of the Nutrition Society

  6. Murgia C, Adamski MM
    Translation of Nutritional Genomics into Nutrition Practice
    Nutrients
    https://doi.org/10.3390/nu9040366

  7. Garg R, Sharma N, Jain SK
    Nutrigenomics and Nutrigenetics: Concepts and Applications in Nutrition Research and Practice
    Acta Medica International

  8. Keathley J, et al.
    A Systematic Review and Recommendations Around Nutrigenetic Evidence
    Frontiers in Nutrition (2021)
    https://www.frontiersin.org/articles/10.3389/fnut.2021.789215/pdf

📊 META-ANALYSES & CLINICAL TRIALS

  1. Khera AV, et al.
    Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
    New England Journal of Medicine (NEJM)

  2. A Randomized Controlled Trial of DNA-Based Dietary Advice for Changing Dietary Behavior
    Scientific Reports (Nature)
    https://www.nature.com/articles/s41598-024-55105-6

  3. Clinical Trial Registry: MTHFR Mutation and B12/Folic Acid
    https://clinicaltrials.gov/study/NCT04952324

📖 KEY GUIDELINES & DATABASES

  1. FDA – Table of Pharmacogenomic Biomarkers
    https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling

  2. CPIC – Clinical Pharmacogenetics Implementation Consortium
    https://cpicpgx.org/guidelines/

  3. GWAS Catalog
    https://www.ebi.ac.uk/gwas/

  4. PharmGKB – Clinical Pharmacogenetics Knowledge Base
    https://www.pharmgkb.org/

  5. ClinVar – NCBI
    https://www.ncbi.nlm.nih.gov/clinvar/

  6. OMIM – Online Mendelian Inheritance in Man
    https://omim.org/

  7. Nature – Nutrigenomics Collection
    https://www.nature.com/subjects/nutrigenomics

 

📘 Pharmacogenomics and Nutrigenomics: Key Reviews & Clinical Applications

🧬 Pharmacogenomics Reviews & Guidelines

  1. Pharmacogenetics Guidelines
    National Center for Biotechnology Information (NCBI)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868558/

  2. Bank PC, et al.
    Comparison of Guidelines Published by DPWG and CPIC
    (Referenced in PMC7868558)

  3. Relling MV, et al.
    Clinical Implementation of Pharmacogenetics
    The Lancet

  4. The Pharmacogenomics Journal
    https://www.nature.com/tpj/

  5. Abdullah-Koolmees H, et al.
    Pharmacogenetics Guidelines: Overview and Comparison
    Duplicate of PMC7868558

  6. Ferguson JF, et al.
    Nutrigenomics, the Microbiome, and Gene–Environment Interactions
    American Heart Association Journal
    https://www.ahajournals.org/doi/10.1161/HCG.0000000000000030

🍏 Application & Practice Reviews in Nutrigenomics

  1. Nutrigenetics and Nutrigenomics: Viewpoints on Application and Future Prospects
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121546/

  2. Advances in Nutrigenomics and Applications in Public Health
    Food and Nutrition Journal
    https://www.foodandnutritionjournal.org/volume10number3/advances-in-nutrigenomics-and-applications-in-public-health-a-recent-update/

  3. Brennan L.
    Nutrigenomics: Lessons Learned and Future Perspectives
    American Journal of Clinical Nutrition
    https://www.sciencedirect.com/science/article/pii/S0002916522006141

  4. Kassem NM, et al.
    Nutrigenomics and Microbiome: Shaping the Future of Nutrition
    Saudi Journal of Biological Sciences
    https://www.sciencedirect.com/science/article/pii/S1687157X23009885

🧪 Specialty Clinical Studies: MTHFR, Folate & Vitamin B12

  1. MTHFR Gene and Folate Metabolism Overview
    MedlinePlus Genetics
    https://medlineplus.gov/genetics/gene/mthfr/

  2. MTHFR Polymorphisms and Vitamin B12 Deficiency
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512882/

  3. Genetic Variants and Folic Acid Clinical Relevance
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789830/

  4. Khan S, et al.
    MTHFR Deficiency and Psychiatric Diseases
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088868/

  5. Pharmacogenomics Overview – StatPearls
    https://www.ncbi.nlm.nih.gov/books/NBK617055/

🥛 Lactose Intolerance & Gene-Food Interactions

  1. Swallow DM
    Genetics of Lactase Persistence and Lactose Intolerance
    Annual Review of Genetics
    https://www.ncbi.nlm.nih.gov/books/NBK532285/

  2. Genetics of Lactose Intolerance – An Updated Review
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551416/

  3. Molecular Genetics of Human Lactase Deficiencies
    https://www.tandfonline.com/doi/full/10.1080/07853890903121033

🌾 GWAS and Food Genomics

  1. Large-Scale GWAS of Food Liking Reveals Genetic Basis
    Nature Communications
    https://www.nature.com/articles/s41467-022-30187-w

  2. Appraisal of Gene–Environment Interactions in GWAS
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750926/

  3. (Repeat) Discovery of MTHFR Variant and Related Impacts
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088868/

 

🧬 Nutrition, Diet & Practical Genomics

🔍 Key Articles & Reviews

  1. The DNA-Based Diet
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224962/

  2. Genetic Testing for Prescription of Diets
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023120/

  3. StatPearls – Lactose Intolerance
    https://www.ncbi.nlm.nih.gov/books/NBK532285/

  4. Journal of Nutrition, Metabolism and Health Science
    Article from Volume 6, Issue 4
    https://jnmhs.com/archive/volume/6/issue/4/article/1918

  5. MTHFR Correlation with Folic Acid and Fetal Malformations
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627646/

  6. Frontiers in Nutrition – Nutrigenomics Section
    https://www.frontiersin.org/journals/nutrition/sections/nutrigenomics/research-topics

🔬 Emerging Research & Reviews

  1. Nature Reviews Genetics – Special Collections
    https://www.nature.com/collections/kgkwwqwTVS/

  2. Personalized Medicine – Nutrigenomics Approaches
    ScienceDirect
    https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/nutrigenomics

  3. Nutrigenomics and Personalized Diet
    https://www.sciencedirect.com/science/article/pii/S2772502225002884

  4. Systematic Review: Nutrigenomics and Cancer
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728558/

  5. Nutrigenetics and Nutrigenomics: Concepts & Applications
    Acta Medica International

📎 Hyperlink Appendix for Digital Use

Use the links below in your digital reports or proposals. For clickable formatting, hyperlink the titles or keywords in your documents.

  1. PMC7923694

  2. AJCN – Brennan, Nutrigenomics

  3. JNMHS – Vol. 6 Issue 4

  4. Food and Nutrition Journal – Nutrigenomics in Public Health

  5. Kassem et al., Nutrigenomics & Microbiome

  6. Pharmacogenetics Guidelines – PMC7868558

  7. Systematic Review: Nutrigenomics & Cancer

  8. Lactase Deficiencies – TandF

  9. MTHFR & B12 Deficiency – PMC11512882

  10. AHA – Nutrigenomics & Gene–Environment

  11. The Pharmacogenomics Journal – Nature

  12. Frontiers Review – Nutrigenetic Evidence

  13. Genetics of Lactose Intolerance – PMC7551416

  14. MTHFR Deficiency – PMC11088868

  15. Frontiers in Nutrition – Nutrigenomics Topics

  16. StatPearls – Pharmacogenomics

  17. Early Review – Nutrigenomics Viewpoints – PMC3121546

  18. Lactose Intolerance – StatPearls

  19. ClinicalTrials.gov – MTHFR & B12/Folate

  20. Nature Article – GWAS & Food Genomics

 

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